Flexibility of β-sheets: Principal component analysis of database protein structures

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Flexibility of beta-sheets: principal component analysis of database protein structures.

Protein folds are built primarily from the packing together of two types of structures: alpha-helices and beta-sheets. Neither structure is rigid, and the flexibility of helices and sheets is often important in determining the final fold (e.g., coiled coils and beta-barrels). Recent work has quantified the flexibility of alpha-helices using a principal component analysis (PCA) of database helic...

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ژورنال

عنوان ژورنال: Proteins: Structure, Function, and Bioinformatics

سال: 2004

ISSN: 0887-3585

DOI: 10.1002/prot.10618